The ENT Carolina Allergy Program                         

Mark E. Reiber, M.D., F. A.C.S., F.A.A.O.A.

The incidence of allergy, asthma and sinus infection is increasing and billions are spent annually on doctor visits and medications. Despite this, surveys show patients are increasingly frustrated and searching for answers. All of this at a time when there are better treatments available than ever before.  What is missing? (Why Patients are so Frustrated)

First, you must determine what is the problem (What's Your Problem?) and then what to do about it (How to Treat Allergies). Allergy testing (Allergy Testing) must be done properly and interpreted for your specific situation.   

Our approach involves all three pillars of allergy treatment:   avoidance measures (Environmental Control), medications (Allergy Medication Overview) and desensitization (Immunotherapy).  When necessary we perform surgery to correct nasal problems (Nasal/Sinus Surgery).  Finally, it is important to set reasonable goals and expectations tod etermine effectiveness (Expectations).

There may be compicating issues affecting  allergy patients and deserving special attention.  These include the impact of foods on respiratory allergy (coming soon),"Sinus" headache (Allergy, Sinusitis and Headache), Asthma (coming soon), and issues effecting athletes (Allergies, Asthma and the Athlete).

At ENT Carolina, we believe strongly in a partnership between patient and physician.  We encourage our patients to take an active role in their care. This is why we have created our website.   We hope you find it useful and welcome your feedback. 

Why Are Patients So Frustrated?

A growing concern  
It seems today almost everyone has allergies. In fact, up to a fourth of all households are affected.  While often considered just a nuisance, allergies can have a significant impact on quality of life.  Worsen over time, allergies may progress to asthma, sinus and ear infections, sleep disturbances, and chronic headaches.

Allergies hit the wallet
The financial impact to allegy is enormous. Half of all workers have allergies and it's the most significant disease affecting productivity.  Sedating medications and compromised sleep increases work related accidents and injury. The direct costs of treating allergic related disease is staggering.

Looking for help
Allergic Americans are searching for answers. In 2002, the Asthma and Allergy Foundation of America survey found fascinating answers as to why patients are frustrated. 

Problem One: Patients are using multiple medications without satisfaction:

An ounce of prevention is better than a pound of cure
No one likes to take medication, however, using medications before symptoms start is vital to control.   The natural tendency is to wait until you are sick. This is the wrong approach.

That’s the best I can do under the circumstances…
For severe cases, medications may be only a partial solution.High level exposures cause symptoms despite medications. Environmental control and immunuotherapy are an important additions to the treatment of allergies.

The right man for the job
A third reason for failure is confusion over what is the right medication for the problem. Not all "allergy medications" are alike.  Some work for itchy, runny, watery symptoms, while others are better for blockage, pressure and congestion.  You have to know what is best for your symptoms.

The right tools for the job
Finally, not everything that seems like allergy is allergy.  Migraines, TMJ and other non-allergic diseases mimic allergies. You must start with the correct diagnosis to get the proper result.

Don’t try this at home…
A qualified specialist can guide you appropriately.  

Problem 2: Patients are discontent with their doctors:

There’s never enough time 
"My doctor doesn’t spend enough time with me". Physicians are being challenged to increase efficiency and yet be compassionate and attentive.  We utilize alternatives resources and extenders for education. ENT Carolina has worked hard on our website resources to better serve our patients.

Know it alls…no, but we are trying
It is not possible for physicians to be experts in every area of medicine.  Treating upper respiratory allergy includes medical and surgical knowledge of  the ear, nose, sinuses, throat, lungs, eyes, and skin. As ENTs (otolaryngologist) we possess the knowledge and skills that uniquely qualifies us to care for nasal allergies.

Problem 3: Patients’ perceived knowledge exceeds actual knowledge:

Not as smart as you think you are (about allergies)
Almost all patients surveyed felt they were “somewhat” or “very” knowledgeable about allergies, but when asked basic questions, the majority answered incorrectly. Up to half of the patients didn’t know the contents of the medications they were taking.

Knowledge is the best medication
We truly believe education is the most powerful weapon for allergies.  Our goal is to provide you with the best, most complete resource available.

 

What’s The Problem?

 
What is Allergy? You know it is sneezing, watery eyes,nasal congestion, and sinus infections, but do you understand it?. What causes allergy? Why do you have allergies? Why do you suffer greatly while someone else has mild symptoms?  What can you do to prevent allergies?
 
You don’t know what you think you know:
Studies show most patients believe they understand their allergies, but when quizzed, less than half knew the immune system was involved.  Few could explain the differences between types of allergy medications or even which type they were taking.
So what do you need to know without having to get a medical degree?
 
Understand the enemy:
 “Antigen” is the smallest protein molecule causing allergic symptoms. When we say you are allergic to cats, it’s not the whole cat, just the Fel protein in saliva that gets on it's hair when licked. Protein antigens are found in pollens, molds and all allergic substances.  
 
The two ingredients of allergies: 
 To be allergic, you must possess both an allergy gene for an antigen, and repetitive exposures to that antigen.
 
Mom and Dad are to blame: 
You get 23 pairs of chromosomes, one from each parent. Each is a long strand of DNA molecules composed of millions of genes instructing the cell how to grow, work and behave. Within immune cells are unique genes for each antigen to which you can be allergic. Rarely is anyone allergic to only one antigen. 
 
How do genes control cell behavior and structure?
Genes are copied into RNA and then made into proteins.  Proteins are the workers performing the function and structure of the cell. In going from DNA to RNA to proteins are many steps for control and regulation.
 
All genes are not alike: 
If one parent has allergies, you have a 1 in 3 chance of developing allergies, and 1 in 2 if both parents are affected. If genes alone accounted for allergies, these numbers should be 50% and 100%, but there are many factors regulating gene expression. Patients with the same “allergy gene” can have different expressions and show mild, moderate or severe symptoms.  
 
Genes alone won’t do it:
Just having the allergy gene isn’t enough, there must be repetitive exposures. With first contact, your system detects, processes, and reacts without symptoms. Subsequent exposures cause increasingly greater responses with a full-blown reaction after the fifth exposure. Studies show your age may affect sensitization.  Exposing young children to cats or certain foods may be more likely to lead to allergy than exposures later in life.
 
How and why do allergic reactions happen?
Our immune system is a complex array of chemical reactions designed to protect us from the outside world. It recognizes foreign from self and eliminates or isolates invaders.
 
The military for the body:
Common invaders include bacteria, viruses, chemical irritants, toxins, and allergens. The symptoms we experience are the consequences of our immune response. Fever, for example, results from the chemical, interleukin.  It raises the body’s temperature to improve immune system efficiency. The itchy, watery nose and sneezing you experience during an allergic attack is from histamine.
 
Friends as the enemy:
When functioning properly, our immune system eliminates foreign substances without harm; however errors can occur. In allergy, commonly encountered substances are recognized as harmful and the response is overly aggressive.
 
A civil war in the body:
 An even greater problem can occur when the immune system mistakenly recognizes its own body as foreign, an “autoimmune” disease. Rheumatoid arthritis and lupus are common examples.   
 
The highway system:
Immune reactions are complex and intertwined like an elaborate interstate highway system or branching roads.   There can be many triggers initiating a reaction and different pathways taken. Viruses, bacteria, toxins, pollutants, and allergens are all triggers. Immune reactions for bacterial and viral infections take different paths, and for allergies, there are at least four unique types of reactions. 
 
Poison ivy is one type of allergic reaction known as delayed hypersensitivity. It takes several hours to develop and relatively minor.   A peanut allergy reaction on the other hand, is immediate and life threatening.  These are completely differernt types of allergic reactions with unique mechanisms. 
 
A powder keg, waiting to explode: 
Once the immune system has been primed by exposures, it is set to react more easily and severely, like an explosion erupting through a fireworks factory. Light one fuse and soon the whole place is exploding. When allergies are bothering you, it may seem like anything will trigger sneezing and dripping. When we treat nasal allergy, we concentrate on prevention and early intervention before things get out of hand.
 
Summary:

            Allergies are a result of your genes

and

your exposures. The immune system is complex and functions as a defense system for the body. Allergy is an overly enthusiastic reaction to common proteins in the environment. There are many triggers, but once your immune system starts reacting it is more likely to do so again, and more severely. Prevention and early intervention is the best approach.

How to Treat Allergies:

Where do you start?
Once you determine allergies are a problem, where do you begin? How do you sort through the many options and find what is right for you?

There are a staggering array of medications claiming to offer relief. Television ads tell you just what to ask from your doctor. There are air purifiers, mattress covers, and duct cleaning services all claiming to save you. Then there are so-called natural remedies, with claims of miraculous success without side effects.

Family members and co-workers are quick to offer suggestions, but this advice is rarely what is best for you.
Frustrated and confused, you may turn to books, the internet, and even strangers who may claim to have the ideal solution. Beware! There is plenty of misinformation and unscrupulous people waiting to take advantage of your desperation.

You may just decide to “try everything”, but this rarely works either. Time, money and energy are wasted, and frustration reaches a point where you feel there is no hope. So what is the best approach? Well, here are a few suggestions.

Stop looking for miracles:
First, understand the problem. Allergy is a chronic disease meaning it can be controlled, not cured. People realize arthritis and diabetes are not cured, and control is not always optimal. A diabetic won’t tell his doctor insulin doesn’t work for him simply because his blood sugar runs high occasionally. An arthritis patient doesn’t stop anti-inflammatory medication because her joints still swell at times.

Unfortunately, this is what allergy sufferers may do. They’ll switch from one medication to the next, looking for the “ideal” cure. They quickly discount helpful treatments as failures if they get less than total or permanent relief.
There’s no magical cure without cost, side effects, or effort. It doesn’t exist now, and never will. Remember, “If it sounds too good to be true, it is”.

Beware:
Whenever there is a problem without a perfect solution, there are people waiting to take advantage of the situation. In the allergy field, there is a wide range in quality of care available. There are practitioners offering less than reputable treatments making outlandish claims.

Be careful, and check with reputable sources before agreeing to any treatment. Take advice from family and friends with the proper amount of skepticism. Remember, no treatment is free of side effects, and all take time to succeed.

Treating allergy is like investing money, aim for the long term, manage your risk, and leave the get rich quick schemes to the foolish.

Find a treatment with which you can live:
Allergy management can be like dieting. Many diets have quick effects, but no diet is truly successful without lasting results. In order to keep weight off, the plan has to be easily incorporated into your life style. Strange fads and inconvenient allergy treatments not part of your daily routine will never be the answer.

Be patient:
Find a plan and stick with it. Make adjustments only when necessary. Decisions about success or failure shouldn’t be made over short periods of time or based on single events. Remember, patients without allergies catch colds and get sinus infections on average once or twice a year, and so will you. So don’t change your plan every time you get sick.

There are three treatments for allergy:
All allergy treatments can be broken down into one of three areas: 1) environmental controls, 2) medications, and 3) immunotherapy or allergy vaccines. In order to better explain the role of each, I created the “house fire theory of allergy”.

The House Fire Theory:
Consider treating allergies like trying to keep from being burned in a house fire. There are three things you can do.
First, limit the fuel for the flames, environmental control. Allergens are the fuel triggering the reactions causing symptoms (“the explosion”).
Secondly, you can throw buckets of water at the flames. Medications are these buckets of water. Highly effective for small fires, they are rarely enough for larger ones. Relief is fast but has no lasting benefits.

Patients often say “I tried antihistamine X, and it just doesn’t work”. “Does a bucket of water put out a fire?” A small fire, yes, but for larger fires it will take other measures. The antihistamine is probably working, but it may not be sufficient to do the entire job.

Finally, the third way to limit getting burned is to put on fire protective clothing, like a fireman's suit. This increases your tolerance for heat. Over time, by taking allergy shots or drops you develop this tolerance or “protective armor”. You raise the threshold for exposures at which symptoms will begin.

Now, let’s look at each one of these three methods in more detail.

Tool One- Environmental Control: Get rid of the fuel for the fire:
This is theoretically the most successful form of treatment. It can be as simple as removing a pet or controlling humidity in your home.
If one can avoid or limit the exposure to allergens, then symptoms will never begin. Most severely allergic patients can’t use this as the sole form of treatment, but it’s still important. Unfortunately, it is often neglected.

Environment controls are mostly for indoor antigens such as dust mites, molds and pets. Techniques do not have to be expensive, but it is important to learn what to do before taking any measures so as not to waste money.

Do not become discouraged. Improvement is the goal, not total avoidance.

Tool Two- Pharmacotherapy: For controlling symptoms:
Medications block symptoms most effectively if given before exposures. There are several classes of medications, including nasal steroids, antihistamines, decongestants, leukotriene inhibitors, and mast cell stabilizers. Combinations can maximize effects and be tailored for symptoms and side effects. A qualified allergy specialist is best suited to determine what is right for you.

Tool Three- Immunotherapy: Building up tolerance:
I have told my patients for years immunotherapy is like saving for retirement in a 401K. You invest regularly for a benefit not realized until the future. For immunotherapy, this might take 6-12 months. If immunotherapy is your retirement savings, then allergy medications are your paychecks, providing relief to spend for today. Our goal is eventually to build up enough tolerance with immunotherapy (savings), so we can stop medications (paychecks).

In the financial world, you wouldn’t save for the future when you couldn’t pay today’s bills. In the allergy world, we don’t give allergy shots or drops when you are severely ill from allergies. We don’t want to add more allergens to the “fire” at times when you are having the most problems. Avoid shots or drops during times of severe worsening.

In conclusion, while allergies may seem frustrating and difficult to manage, treatment always comes back to the three areas:  environmental control, medications and immunotherapy.  Each of these is covered in greater detail in other overviews.

Allergy Testing:

When should I get tested?
If you have symptoms more than three months a year, despite medications and environmental control, then it’s time for allergy testing.

There are two goals:   to properly direct avoidance measures and to enable immunotherapy. It isn't reasonable to cover mattresses or exile the cat if  you aren't sure dust mites and pets are the problem.  Each positive skin test identifies a particular allergy.  If you are allergic to 10 common antigens in the area, then a mixture of these allergens is made for injections or as drops under the tongue.

How is the test done?
There are many different methods of testing and variation among doctors. Results can vary greatly depending on the type of testing performed.

At ENT Carolina, we use a combination of a prick and intra-dermal test called modified quantitative testing (MQT). It takes approximately an hour for 40 tests. Prick testing uses an 8 pronged, plastic device gently creating a small wheal in the skin of the arms. With positive reactions, no further testing is required. For negative results, a small TB needle is used to raise a skin wheal read in 10 minutes.

What am I tested for?
Our carefully selected panel includes the area’s most common weeds for the fall, grasses for the summer and fall, trees for the spring, molds, animal dander and other non-pollens for year long problems. Some antigens are so structurally similar to others, they do not have to be tested individually (cross-reactivity).

What about food allergies?
We do not do skin testing for foods for a number of reasons. In most cases, other than patients under 5 years of age, we believe food allergies are not significantly responsible for upper respiratory tract diseases. In addition, we recommend elimination and challenge diet testing as the gold standard test when necessary. Anaphylactic (shock) allergy to foods do exist such as shellfish and peanut allergies and cause life threatening swelling, and airway compromise. These should be diagnosed with blood testing (RAST) and treated with avoidance, not immunotherapy.

Can I have a blood test for allergies?
There are occasions when blood testing (RAST) for environmental allergies is recommended. We find blood testing to be less sensitive than skin testing, especially for molds, and we limit its use to only a few situations.

Can you use previous allergy test results from other doctors’ offices?
There are times when this is possible for making sublingual immunotherapy SLIT, but not injections (SCIT).

Are there medications that can affect my testing?
It is very important to inform us of all medications you are taking prior to testing. Antihistamines or medications with antihistamine like effects will block reactions giving false negatives. A class of anti-hypertensive medication, known as “beta blockers”, is specifically contraindicated for both testing and immunotherapy. They block the effectiveness of rescue medications used in the unlikely event of an anaphylactic reaction.

What can I expect after the test?
Patients will often note delayed skin reactions usually to molds. This is normal, but these reactions can be large and bothersome. Cortisone cream and an oral antihistamine can help with itching and redness.

Are there any risks to allergy testing?
Risks include: itching, nasal congestion or drainage, throat tightness, cough, or breathing difficulty. These can progress to more severe, potentially life-threatening situations such as anaphylactic shock or death.

Can I be tested if I am pregnant?
Patients who are pregnant should not be allergy tested. Patients who become pregnant while on immunotherapy may continue at the current dose but may not advance on therapy until after delivery.

Environmental Control for Allergies

The purpose of this article is to introduce environmental control and to stress its importance in your treatment plan. Ignoring it, may lead to treatment failure despite medications and immunotherapy. On the other hand, one can easily waste considerable time and money on unnecessary and inappropriate measures. This article doesn’t cover everything you need to know, but I hope it motivates your to do further research.

Basic Information:           

What is an allergic reaction?
                       
An allergic reaction is an immune response to an allergen causing sneezing, congestion, runny nose, asthma and other symptoms. Allergens are biologic proteins recognized by the body as foreign and harmful.
 
What is a non-allergic trigger?      
           
Non allergic triggers are irritants and non-protein materials setting off an allergic-like reaction. Examples are strong chemicals such as formaldehyde, gasoline, perfumes, cleaning materials and cigarette smoke.
 
How do I treat allergies?
 
Treatment involves limiting triggers (environmental control), decreasing immune responses (medications) and desensitization (immunotherapy) to raise the threshold for reaction. Non allergic triggers are treated by avoidance and medications but not immunotherapy
                       
 “I am allergic to everything, so I can’t do avoidance measures”  
 
This simply isn’t true. While total avoidance is impossible, limiting frequency and amount of exposures is beneficial.    
 
Your immune system has a level of tolerance to all allergens. The “total load” is the sum of all exposures and when it exceeds your tolerance, you have symptoms. The goal is to reduce the total load.
 
Allergic patients have greater sensitivity to non-allergic triggers. Reducing irritant exposures will improve your symptoms. Similarly, if you control allergies (with medications and immunotherapy), you will have less severe reactions to irritants.
 
Now let’s look at the different environments for allergen exposure and the best methods for control.
                      
 
Indoor Allergens
 
Most environmental control measures are aimed at indoor allergens such as dust mites, pet dander, cockroaches and molds. 
 
In your home, the bedroom should be the focus of your efforts as this is where you spend the majority of time. Other problem areas include damp basements, bathrooms and in areas with current or past water damage.
 
Indoor air quality is determined by a wide range of irritants including traditional allergens (pet dander, mold, dust mites), chemicals (formaldehyde, other petrochemicals), and dangerous toxins (radon). Each one of these can serve as a trigger.
 
1. Pets:  
 
Cats are some of the most difficult allergens to control. I call cats the “nuclear material” of the allergy world. It’s not that I don’t like cats, it’s because their ntigens are lightweight and stable for a long time. You stir up cat dander just by walking through a room and moderate levels can still be detected years after the cat has been removed.   In addition, cat dander can stick to materials.  A new mattress in a department store, will show high levels of cat antigen within two weeks just from people with cats “testing it out”. I have even seen symptoms arise just from being around people who have cats.
 
I strongly recommend for indoor cats to be excluded from your bedroom at all times.   I do not recommend bathing a cat as the antigen is in their saliva, and the first thing a cat does after bathing is lick its fur.  
 
Dogs are also antigenic, but not much as cats. Attempts have been made to breed non-antigenic cats and dogs with some success. Unfortunately, they’re very expensive (thousands of dollars) and difficult to find. 
 
The length of the animal’s hair is probably not very important and there is no good evidence to support the claims of certain breeds of dogs being beneficial for asthmatics.
 
Studies do vary in whether early exposure to pets in infancy increases or decreases the risk for sensitivities. I would recommend using common sense. If a child shows significant allergies early on, limit additional exposures such as pets as much as possible.
 
2.  Dust mites:
 
Dust mites are microscopic insects feeding on shed skin cells found in mattresses, upholstered furniture, carpet and stuffed animals. They require 50% humidity to survive and are not found at high altitudes such as in Denver, Colorado (unfortunately they are in Denver, NC).
 
Control methods include dehumidifiers to maintain levels at 45% , allergenic covers for mattresses and pillowcases, and HEPA filter vacuums. Sprays to apply to carpet can be useful but require repeated use. Stuffed animals can be frozen to kill dust mites and then “fluffed” in the drier to remove debris. Since dust mites do not fly, air filtration systems are of no benefit.
 
Keeping your bedrooms as free as possible of carpeting, upholstered furniture and stuffed animals limits the possible “load” of dust mites in a room. Sheets should be washed weekly in hot water as well.
 
 
3. Dust:
 
Dust is composed of dirt, fibers, insect debris, and food particles unique to every home. Evidence suggests “old” house dust is more irritating than “new” dust.    The only control method is general cleaning. It is best to have someone other than the patient to do this. Masks are somewhat beneficial, but can not be depended on for complete protection. When heavy exposure is expected, you can pretreat with medications such as antihistamines and nasal steroids. Some studies suggest saline gels applied in the nose will trap pollens and irritants and prevent them from contacting the nasal lining. Saline nasal sprays or rinses during and after exposures may be beneficial. 
 
Air filters and cleaners are also useful, but probably overemphasized in their importance. Ozone generating air purifiers are best avoided and potentially dangerous. 
 
4.  Indoor Molds:
 
Water and food (organic material) are the two essential elements for mold growth. Removing the water source is the most important technique to controlling molds. Dehumidification, restoring drainage or eliminating damp, wet materials is critical to long term success. Bleach and other cleaning agents will kill visible molds but it will recur quickly if the water supply isn’t eliminated. 
 
To fix basement and crawl space moisture problems may require installing proper drainage away from the house. Water leaks soaking carpet and pads may need replacement or at least extensive drying. I never recommend cleaning up large mold problems yourself. Enlist professionals for this work. Even minor manipulation can aerosolize  molds and cause severe pulmonary disorders and even death.
 
Mold testing in the home is a “tricky” business. I do not believe that random air samples demonstrating molds is adequate to define the problem. Generally a source of the mold must be found, tested and addressed. Room dehumidifiers are of benefit, but must be cleaned and maintained to prevent them from become another potential source of the problem. Entire home dehumidifiers are less effective.   
 
5.  Cockroaches:
 
Cockroaches are everywhere, but they are more prevalent in older buildings and large urban areas. Cockroach allergens have been associated with asthma. Eliminating food and water sources and are critical to controlling cockroach populations.           
 
6.  Irritants and Toxins: 
 
While not technically allergies, the reactions are similar and control is important.
The Environmental Protection Agency (EPA) maintains a very nice website outlining many issues regarding indoor air quality.  (EPA website http://www.epa.gov/iaq/ia-intro.html, Radon EPA website http://www.epa.gov/radon/index.htmlIn addition I recommend a blog specifically about this tissues: http://www.mayindoorair.com/blog/ .
 
Outdoor allergens:
 
The offending outdoor pollens are trees in the spring, grasses in summer and weeds in the fall.   I often hear patients say “I have a lot of trees in my yard I am allergic to, should I cut them down?”   The answer is “no”. These pollens are in the air and dispersed widely, so you won’t make much difference by cutting down a few trees. 
 
I don’t like advice of “stay inside” as this is not practical. I do think that you can choose times to be outside especially for exercise.
 
It can be important to know at what times of the day pollen and mold counts are highest. You can try and avoid exercising or working outside at these peak hours. 
 
           
Conclusion:
 
Environmental control continues to be an evolving area of allergy care. I recommend you do your own research and do not necessarily rely on one source. So much of the information out there is biased and motivated by selling a product or service. Be informed. Be skeptical, and be cautious. Spending more money doesn’t correlated to better results.
 

Allergy Medication Overview:

Introduction:
There are two critical concepts all allergy patients need to know:

  1. Treatment has three components:  environmental control, medications, and immunotherapy.
  2. Allergies are a chronic disease in which “prevention is better than rescue”.   This is particularly true for medication use.

This overview covers the major classes of medications used to treat nasal and ocular allergies but not asthma, allergic bronchitis or lower respiratory disorders. Popular trade names and generics are listed, but it’s not a comprehensive list. 

You should discuss any medication with your ENT Carolina physician before initiating. This overview is for general education and does not replace consultation with your physician.  Package inserts contain detailed information about medications and web links are provided to sites with reviews of medications.

Topical Nasal Steroid Sprays: (Flonase®, Nasacort®, Nasanex®, Rhinocort® Veramyst®)
http://www.drugs.com/pdr/nasonex.html

These are the “work horses”. More than a decade ago, I coined the phrase “toothpaste for the nose”  to emphasize their safety and importance. Even though they are “steroids”, they have limited absorption outside of the nose making them safe for daily use. They are much less effective when used "as needed". 

Nasal steroids target many sites of the immune response and are like using multiple medications at once. This is one reason they are more useful than antihistamines that block only histamine.

Proper technique is critical to limiting side effects. Direct spray toward the outside of the nose, away from the midline (septum) and the nose’s blood vessels. We call this technique “cross your heart” using the opposite hand from the side of nose (right hand, left nostril, and vice versa). This minimizes nosebleeds and trauma to the septum.

Nasal steroids are typically first line therapy for chronic symptoms of congestion, runny nose, ear fullness, and polyps. They are also valuable for a special condition called allergic fungal sinusitis. Seasonal allergy patients benefit from starting before symptoms begin and continuing through the season.

Topical Antihistamines: (Astepro® Patanase®)

http://www.drugs.com/astepro.htm

These nasal sprays provide fast relief from drainage, congestion, and “itchy” nose. They're best used prior to exposure but daily use isn't necessary. They're are “rescue” drugs for times of heavy exposure and symptoms and effective for non-allergic triggers such as cigarette smoke, perfume, soaps and other strong odors/ irritants. Unpleasant taste is reported.

Topical Nasal Decongestants: (Afrin®, Neo-Synephrine®)
http://www.drugs.com/mtm/A/Afrin.html

These over the counter sprays are for short term use only, usually 3 days or less. Longer use can lead to rebound congestion and dependency (rhinitis medicomentosa). They are ideal during colds and sinus infections and for stopping active nose bleeds.

Topical Mast Cell Stabilizers:( Nasalcrom®)
http://www.rxlist.com/cgi/generic/cromnas_ad.htm

This over the counter spray has limited side effects, but requires four times per day dosing and must be used prior to exposure. Its usefulness is very limited (occasional exposures such as pets at relatives you rarely visit).

Topical Anti-Cholinergics: (Atrovent®)
http://www.mayoclinic.com/health/drug-information/DR202713

Vasomotor rhinitis is a watery nose after eating, in cold weather, with viral infections, during times of stress, or simply chronically without response to antihistamines or steroid nasal sprays. It is common in older patients but exclusively. It may accompany allergies and combining Atrovent® with steroid nasal sprays is often beneficial. This spray is available in 0.3% and 0.6% strengths, with the stronger strength indicated for viral infections such as the common cold. Dosing is three times per day.

Oral Anti-Histamines: (Allegra, Clarinex, Zyrtec, Claritin, Benadryl)
http://www.rxlist.com/cgi/generic/fexofen_ad.htm
http://www.medicinenet.com/desloratadine-oral/article.htm
http://www.drugs.com/pdr/zyrtec.html
http://www.healthsquare.com/newrx/ben1050.htm

Oral antihistamines are the most commonly used allergy medications. Diphenhydramine (Benadryl) is one of the oldest . Newer generation anti-histamines have reduced sedation while maintaining effectiveness.

Non-sedating antihistamines are much safer than older anti-histamines that cause significant cognitive and reflex impairment, and sedation. Studies have shown significant effects on school and job performance and driving impairment.  Patients often use diphenhydramine as a sleep aid, and while it does cause sedation, studies have shown it provides a very poor quality of sleep and causes a significant hang-over effect.

Non-sedating antihistamines are best used for watery and itchy symptoms, sneezing, and rashes or hives but are not  effective for nasal congestion or facial/ear pressure, or chronic post-nasal drainage.

Combination products (“D” after the name) contain psuedoephedrine, a decongestion, which may cause palpitations, excitability, insomnia or other side effects.

Leukotriene Inhibitors: (Singulair®, Accolate®)
http://www.drugs.com/singulair.html

Originally introduced for asthma, they now have indications for allergic rhinitis and are suitable for patients with both problems.  They specifically address congestion, facial pressure, and cough. Patients may need to combine with nasal steroids or antihistamine for itchy, watery, and sneezing symptoms.

Taken orally once daily, they are well tolerated with few side effects and may be a good substitute for oral decongestants with long term use.

Systemic Steroids: (Medrol®, Decadron®, Kenalog®, prednisone)
http://www.healthsquare.com/newrx/med1251.htm

Systemic steroids are available as intramuscular injections or tablets for short term use. They are the most potent and effective anti-inflammatory medications, but clearly have the greatest potential for side effects. Most side effects are associated with long term use, but rare complications are reported with short term or single dose use.

A severe allergy attack, unrelieved by other medications, may be treated with systemic steroids. Nasal polyps, allergic fungal sinusitis and asthma are other conditions for steroids. Extreme care must be used in diabetic patients and other medical conditions.

Ophthalmic Preparations: (Patanol®, Optivar®, Zaditor®, Pataday®)
http://www.drugs.com/Patanol.html
http://www.drugs.com/MTM/O/Optivar.html

Allergy eye drops vary greatly in their mechanisms of action. There are antihistamine, anti-inflammatory, mast cell stabilizer, steroid, decongestant, lubricant, and combination products. Dosing is once or twice a day and specific care may be required for contact lens wearers.
Drops can provide relief from itching, watering and burning of allergic conjunctivitis.

Saline Nasal Spray and Gel: (Ayr®, Ocean®)

Salt water formulations of sprays and gels can be found under various trade names and purchased without prescription. They moisturize the nose and prevent allergens from accumulating on the nasal lining. Dosing is "as needed" and safe to use many times a day. Gels work well at night time by coating the nose for a longer effect.

More information on allergy medications can be found at:
http://www.webmd.com/content/article/61/67462
http://www.aaaai.org/patients/publicedmat/tips/asthmaallergymedications.stm
http://www.mayoclinic.com/health/allergy-medications/AA00037

Mayo Clinic's Medication Information

Immunotherapy:

History of immunotherapy:
Immunotherapy was first reported in 1911 as repeated injections with pollens to induce tolerance, a “vaccine for allergy”. In general, each allergen to which a person is allergic must be treated individually and a mix is created based on testing. The exception is some antigens are so similar in structure to others that they can elicit tolerance for each other allowing smaller numbers of allergens to be used.

Allergy “shots” are accepted:
Minor modifications to subcutaneous immunotherapy (SCIT, or allergy shots) have occurred, but it has been the dominant form of therapy for a century. It’s proven effective for pollens, molds, cats, dogs, dust mites and cockroach antigens for asthma and allergic rhinitis.

How SCIT works:
Ten weekly doses are given, increasing the amount each week. Then a five times stronger mixture is made and the process starts again.  This continues until a maximum concentration is reached or the patient experiences reactions preventing further advancement. It may take a year to reach this point.

Once maintenance is reached, weekly injections are given for 3-5 years. If symptom relief is maintained, shots are tapered and discontinued. A majority of patients develop lasting effects, but a small percentage needs to continue shots beyond the five year point.

The downsides to allergy shots:
SCIT is not without small risks and disadvantages. Weekly office visits, with a 20 minute wait following injection, can become inconvenient and difficult to maintain. Rare reactions include local skin reactions, shortness of breath, and even shock. Very rarely, death has been reported, usually in asthmatics. These factors motivated research to find alternative forms of immunotherapy.
 
Looking for alternatives- SLIT is born:
As early as 1913, alternatives such as nasal and oral routes were proposed. Oral therapy includes direct swallow and sublingual (under the tongue) methods (SLIT).   In 1998 the World Health Organization approved both the sublingual and nasal methods as viable alternatives to SCIT.  Nasal delivery proved to be difficult and less accepted. Oral immunotherapy with immediate swallowing is less effective than SLIT (held under the tongue). 

SLIT- the basics: 
At ENT Carolina, we offer SLIT and follow the American Academy of Otolaryngic Allergy dosing recommendations. Patients start at a standard concentration and advance over twelve weeks to a maximum strength for one year. If satisfactory response is not seen by a year, therapy is stopped but for the great majority of patients who respond, continue for 3-5 years.  At the end of 5 years, a small percentage require longer therapy, but most develop persistent symptom relief.

How SLIT works: 
It appears the effectiveness of SLIT correlates with the duration of contact with the mouth’s lining. There may be a critical interaction between the immune cells of the floor of the mouth and this effectiveness. It is important to watch the clock to ensure 2 minutes of exposure time. Dosing is performed once daily.
 

Effectiveness of SLIT has been based on reports of symptom decrease and reduced dependency on medications. Duration of at least three years appears necessary but we recommend 4-5 years. Pollen therapy appears most effective with dust mite and pets requiring longer times. We generally see effects beginning in about six months or less.

The downsides to SLIT:
Only occasional mild reactions such as oral itching, headache, runny nose, hives, constipation or other gastrointestinal side effects are  seen. To date there have been only a few episodes of anaphylaxis world-wide, and no deaths, associated with SLIT. These reports were all in non-inhalant allergens that we do not use. 

Sublingual immunotherapy is prepared from the same FDA approved antigen extracts used for subcutaneous therapy; however, the FDA has not approved sublingual administration. This is an "off-label" use.  Off-label use of medications is very common with estimates of 25-50% of all prescriptions being for off-label indications. The studies and review needed to obtain FDA approval are underway at this time.  Experience in Europe for over 30 years has demonstrated safety and efficacy but American data is just beginning to become available.

In 2005, the Asthma and Allergy Foundation of America performed a survey of allergy patients asking about the important features of an allergy medication.  These features were important to 50% or more of respondent.  I have shown how these features relate to SLIT.

 

SCIT-shots

SLIT- drops

Long lasting symptom relief

Yes

Yes

Rapid relief of symptoms

No (months)

No (months)

Minimal side effects

Yes, but more than SLIT

Yes

No sedation/ Drowsiness

Yes

Yes

Covered by insurance

Sometimes

No

Inexpensive

Depends on ins. benefits

Less than $20/ week

Safe with other medications

Yes, except Beta Blockers

Yes, except Beta Blockers

Easy to take

Requires office visits

Home based, 2 min/day

Non-habit forming

Yes, but must use weekly

Yes, but must use daily

Dosing flexibility (as needed)

No, must use weekly

Somewhat, but should use daily

Targets specific symptoms

No, works on all

No, works on all

Steroid free

Yes

Yes

So why would someone choose one form over another?  Subcutaneous immunotherapy is time tested for over a century. In addition, insurance companies have generally provided better benefits for SCIT than SLIT.  Sublingual immunotherapy is  newer, but has in over a decade of my experience had very positive results. European studies show efficacy similar to subcutaneous therapy for several antigens. There is the obvious benefit to a home based, self administered, needle-less therapy. The safety and side effect profiles of SLIT appear superior to SCIT. For many patients, there is not a significant cost difference even with “insurance coverage” so they would just prefer the ease and convenience of “allergy drops”.

Expectations:

Wouldn’t it be wonderful if you could just take a pill or a shot and never be sick again? If you are faithful with allergy shots or drops, shouldn’t you be rewarded by not having sinus infections? Why put in all that time, money and effort if you are still going to get sick? It just isn’t fair!

Well, those expectations are unrealistic, but that doesn't mean you shouldn't notice considerable improvement. Upper respiratory problems like sinus infections are caused by several factors. Allergy treatment doesn’t prevent all causes like colds, and so you will still get sick. The average person will get 2 respiratory tract infections per year. If you are around children or deal with the public, you might even experience more.

So what can you expect if you try the program?  The goal is to improve and decrease allergy related problems. Results will not occur immediately and I recommend judging success at about one year. Look back on the last 6 months and determine if your symptoms improved and your quality of life is better. If you honestly can’t see improvement, then it probably isn’t worth continuing. We find however the majority of patients benefit greatly from following a course of environmental control, carefully chosen medications and immunotherapy.